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Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

3 Oct 2022

Abstract excerpt

The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease. Here, we have used yeast display of a synthetic nanobody library to isolate nanobodies that bind the receptor-binding domain (RBD) of SARS-CoV-2 and neutralize the virus. We show...

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PMID: 36213007
DOI: 10.1016/j.isci.2022.105259

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