Article
Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis.
Trends in molecular medicine - 1 Aug 2015
Taymans Jean-Marc, Nkiliza Aurore, Chartier-Harlin Marie-Christine
Abstract excerpt
Protein translation is one of the most fundamental and exquisitely controlled processes in biology, and is energetically demanding. The deregulation of this process is deleterious to cells, as demonstrated by several diseases caused by mutations in protein translation machinery. Emerging evidence now points to a role for protein translation in the pathogenesis of Parkinson's disease (PD); a debilitating...
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