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Article

Control of mRNA Translation in ALS Proteinopathy

23 Mar 2017

Abstract excerpt

Cells robustly reprogram gene expression during stress generated by protein misfolding and aggregation. In this condition, cells assemble the bulk of mRNAs into translationally silent stress granules (SGs), while they sustain the translation of specific mRNAs coding for proteins that are needed to overcome cellular stress. Alterations of this process are deeply associated to neurodegeneration. This is the case of...

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PMID: 28386218
DOI: 10.3389/fnmol.2017.00085

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