Huntington's disease: underlying molecular mechanisms and emerging concepts.

doi:10.1016/j.tibs.2013.05.003

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Article

Huntington's disease: underlying molecular mechanisms and emerging concepts.

Trends in biochemical sciences - 1 Aug 2013

Labbadia John, Morimoto Richard I

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative disorder for which no disease modifying treatments exist. Many molecular changes and cellular consequences that underlie HD are observed in other neurological disorders, suggesting that common pathological mechanisms and pathways may exist. Recent findings have enhanced our understanding of the way cells regulate and respond to expanded polyglutamine...

Topics

Animals
Brain
Energy Metabolism
Gene Expression Regulation
Humans
Huntingtin Protein
Huntington Disease
Mitochondria
Models, Biological
Molecular Targeted Therapy
Mutation
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Oxidative Stress

Peptides

Proteasome Endopeptidase Complex

Protein Folding

Protein Stability

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Identifiers

PMID: 23768628
DOI: 10.1016/j.tibs.2013.05.003
PMCID: PMC3955166

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