Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions

Abstract excerpt

ABSTRACT Heart failure (HF) is an end-stage cardiovascular syndrome caused by structural or functional cardiac abnormalities. Its high morbidity and mortality underscore the urgent need for novel therapeutic strategies. In recent years, the dynamic regulatory mechanisms underlying macrophage polarization in the onset and progression of HF have attracted widespread attention. The Sirtuin family, as NAD +...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Ischemia and Reperfusion
• Share to Signaling Pathways in Disease
• Share to Sirtuins and Resveratrol in Medicine