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Article

Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice

28 Jun 2023

Abstract excerpt

AIMS: The mechanisms underlying ageing-induced vascular remodelling remain unclear. This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase sirtuin 2 (SIRT2) in ageing-induced vascular remodelling. METHODS AND RESULTS: Transcriptome and quantitative real-time PCR data were used to analyse sirtuin expression. Young and old wild-type and Sirt2 knockout mice were used to explore...

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PMID: 37377116
DOI: 10.1093/eurheartj/ehad381

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