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Article

WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum

27 Nov 2017

Abstract excerpt

Significance Mycobacteria use ESX systems to transport protein substrates across the cytoplasmic membrane. The ESX-1 system is required for mycobacterial pathogenesis in Mycobacterium tuberculosis ( M. tb ), the cause of tuberculosis (TB). Differences in the expression of genes encoding ESX substrates directly impacts M. tb transmission and virulence. Deletion of genes encoding ESX exporters results in reduced...

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PMID: 29180415
DOI: 10.1073/pnas.1710167114

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Related research

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Research trail→

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WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinumPMID 29180415Read ↗

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaSemantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

EspM Is a Conserved Transcription Factor That Regulates Gene Expression in Response to the ESX-1 SystemSemantic proximity Read ↗

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read ↗

The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in <i>M. marinum</i>Semantic proximity Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in <i>M. marinum</i>Semantic proximity Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinumSemantic proximity Read ↗

Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinumSemantic proximity Read ↗

Esx Paralogs Are Functionally Equivalent to ESX-1 Proteins but Are Dispensable for Virulence in Mycobacterium marinumSemantic proximity Read ↗

Correlation of phenotypic profiles using targeted proteomics identifies mycobacterial esx-1 substrates.Semantic proximity Read ↗

Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene ExpressionSemantic proximity Read ↗

Homeostasis of N-α-Terminal Acetylation of EsxA Correlates with Virulence in Mycobacterium marinumSemantic proximity Read ↗

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