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Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene Expression

2 Sept 2020

Abstract excerpt

Mycobacterium tuberculosis , the cause of human tuberculosis, and Mycobacterium marinum , a nontubercular pathogen with a broad host range, require the ESX-1 secretion system for virulence. The ESX-1 system secretes proteins which cause phagosomal lysis within the macrophage via an unknown mechanism. As reported elsewhere (R. E. Bosserman et al., Proc Natl Acad Sci U S A 114:E10772–E10781, 2017,...

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PMID: 32900815
DOI: 10.1128/iai.00289-20

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Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene ExpressionPMID 32900815Read ↗

EspM Is a Conserved Transcription Factor That Regulates Gene Expression in Response to the ESX-1 SystemSemantic proximity Read ↗

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinumSemantic proximity Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in <i>M. marinum</i>Semantic proximity Read ↗

The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in <i>M. marinum</i>Semantic proximity Read ↗

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspFSemantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaSemantic proximity Read ↗

Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinumSemantic proximity Read ↗

Esx Paralogs Are Functionally Equivalent to ESX-1 Proteins but Are Dispensable for Virulence in Mycobacterium marinumSemantic proximity Read ↗

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The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinumSemantic proximity Read ↗

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