Article

A Deficiency in SUMOylation Activity Disrupts Multiple Pathways Leading to Neural Tube and Heart Defects in <i>Xenopus</i> Embryos

2019-02-13

Abstract excerpt

<h4>Background</h4> Adenovirus protein, Gam1, triggers the proteolytic destruction of the E1 SUMO-activating enzyme. Microinjection of an empirically determined amount of Gam1 mRNA into one-cell Xenopus embryos can reduce SUMOylation activity to undetectable, but nonlethal, levels, enabling an examination of the role of this post-translational modification during early vertebrate development. <h4>Results</h4>...

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Literature Corpus work: 59f3f927-07ef-56d5-919a-6d550e5f2c50
DOI: 10.1101/549105

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