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Article

Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway.

The EMBO journal - 16 Oct 2000

Yamanaka S, Zhang X Y, Maeda M, Miura K, Wang S, Farese R V, Iwao H, Innerarity T L

Abstract excerpt

NAT1/p97/DAP5 is a newly identified protein that shares homology with the translation initiation factor eIF4G. Studies in vitro and in transfected cells indicated that NAT1 might suppress global translation, thereby repressing cellular proliferation. Here we studied the functions of NAT1 in vivo by disrupting its gene in mice. NAT1(-/-) embryos died during gastrulation, indicating a crucial role for NAT1 in...

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Source

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Identifiers

PMID: 11032820
DOI: 10.1093/emboj/19.20.5533
PMCID: PMC314019

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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