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Article

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

Developmental cell - 16 Aug 2011

Lee Florence Y, Faivre Emily J, Suzawa Miyuki, Lontok Erik, Ebert Daniel, Cai Fang, Belsham Denise D, Ingraham Holly A

Abstract excerpt

Sumoylation is generally considered a repressive mark for many transcription factors. However, the in vivo importance of sumoylation for any given substrate remains unclear and is questionable because the extent of sumoylation appears exceedingly low for most substrates. Here, we permanently elim...

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Identifiers

PMID: 21820362
DOI: 10.1016/j.devcel.2011.06.028
PMCID: PMC3157481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21820362-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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