Article

Species-specific oscillation periods of human and mouse segmentation clocks are due to cell autonomous differences in biochemical reaction parameters

2019-05-26

Abstract excerpt

While the mechanisms of embryonic development are similar between mouse and human, the tempo is in general slower in human. The cause of interspecies differences in developmental time remains a mystery partly due to lack of an appropriate model system 1 . Since murine and human embryos differ in their sizes, geometries, and nutrients, we use in vitro differentiation of pluripotent stem cells (PSCs) to compare th...

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Literature Corpus work: 59edf69b-f729-5479-bcff-0f3704ac86e4
DOI: 10.1101/650648

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