Article

A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals

2022-10-14

Abstract excerpt

Differential speeds in biochemical reactions have been proposed to be responsible for the differences in developmental tempo between mice and humans. However, the underlying mechanism controlling the species-specific kinetics remains to be determined. Using in vitro differentiation of pluripotent stem cells, we recapitulated the segmentation clocks of diverse mammalian species varying in body weight and taxa: mar...

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Literature Corpus work: b90ce722-d086-51e5-8bfa-05a976256838
DOI: 10.1101/2022.10.13.512072

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