Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rap1A Regulates Osteoblastic Differentiation via the ERK and p38 Mediated Signaling

24 Nov 2015

Abstract excerpt

Rap1A is a member of small G proteins belonging to the Ras family. Recently, an integration of human genome-wide association studies (GWAS) and gene expression profiling study revealed that single-nucleotide polymorphisms (SNPs) within human Rap1A were strongly associated with narrow neck width in women. However, the regulatory role of Rap1A in osteoblasts remains to be elucidated. Here we report that Rap1A is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone health and treatments
Share to Bone Metabolism and Diseases
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26599016
DOI: 10.1371/journal.pone.0143777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rap1A Regulates Osteoblastic Differentiation via the ERK and p38 Mediated SignalingPMID 26599016Read ↗

Runx2 expression and action in chondrocytes are regulated by retinoid signaling and parathyroid hormone-related peptide (PTHrP)Semantic proximity Read ↗

Ras and Rap1: A tale of two GTPases.Semantic proximity Read ↗

p38 MAPK Signaling in Osteoblast DifferentiationSemantic proximity Read ↗

mTORC1 Signaling Promotes Osteoblast Differentiation from PreosteoblastsSemantic proximity Read ↗

Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesisSemantic proximity Read ↗

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathwaySemantic proximity Read ↗

mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression.Semantic proximity Read ↗

Signaling pathways governing osteoblast proliferation, differentiation and function.Semantic proximity Read ↗

Long non‑coding RNA RP11‑84C13.1 promotes osteogenic differentiation of bone mesenchymal stem cells and alleviates osteoporosis progression via the miR‑23b‑3p/RUNX2 axisSemantic proximity Read ↗

Knockdown of FOXA1 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the ERK1/2 signalling pathwaySemantic proximity Read ↗

The regulatory effect of miR-181c-5p on the differentiation function of bone marrow mesenchymal stem cells in postmenopausal osteoporotic miceSemantic proximity Read ↗

Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.