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Article

Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects.

Human mutation - 1 Dec 2017

Ghosh Somadri, Huber Céline, Siour Quentin, Sousa Sérgio B, Wright Michael, Cormier-Daire Valérie, Erneux Christophe

Abstract excerpt

The SH2 domain containing inositol phosphatase 2 (SHIP2) dephosphorylates PI(3,4,5)P3 to generate PI(3,4)P2, a lipid involved in the control of cell migration and adhesion. The INPPL1 gene that encodes SHIP2 has been found to be mutated in several cases of opsismodysplasia (OPS), a rare autosomal recessive chondrodysplasia characterized by growth plate defects and delayed bone maturation. Reported mutations often...

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Identifiers

PMID: 28869677
DOI: 10.1002/humu.23321

Genes

INPPL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects.PMID 28869677Read ↗

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