Article

Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinoma

2023-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Increased utilization of glucose is a hallmark of cancer. Several studies are investigating the efficacy of glucose restriction by glucose transporter blockade or glycolysis inhibition. However, the adaptations of cancer cells to glucose restriction are unknown. Here, we report the discovery that glucose restriction in lung adenocarcinoma (LUAD) induces cancer cell de-differentiation, leading to...

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Literature Corpus work: 3c68038c-8aa9-583e-9c00-7f14de75eca6
DOI: 10.1101/2023.01.30.526207

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