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Article

Shared PRAME Epitopes are T-Cell Targets in NUT Carcinoma

2025-03-12

Abstract excerpt

<h4>Background</h4> NUT carcinoma is a rare but highly lethal solid tumor without an effective standard of care. NUT carcinoma is caused by bromodomain-containing NUTM1 fusion oncogenes, most commonly BRD4::NUTM1 . BRD4::NUTM1 recruits p300 to acetylate H3K27 forming expansive stretches of hyperacetylated chromatin called “megadomains” with the overexpression of corresponding oncogenes, including MYC . We hypo...

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Identifiers and source

Literature Corpus work
63647d3a-6d0e-58a0-9827-7dfc8d84a3ff
DOI
10.1101/2025.03.07.642090
Open publication

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Shared PRAME Epitopes are T-Cell Targets in NUT CarcinomaDOI 10.1101/2025.03.07.642090
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