Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2025

Kim Justin J, Walton Sara A, Mahadevan Navin R, Haradon Jessica, Paoloni Francesco, Paik Paul K, Chaft Jamie E, Hsu Robert, Piha-Paul Sarina A, Jänne Pasi A, Barbie David A, Sholl Lynette M, DuBois Steven G, Hanna Glenn J, Shapiro Geoffrey I, French Christopher A, Luo Jia

Abstract excerpt

PURPOSE: NUT carcinoma (NC) is an underdiagnosed, poorly differentiated squamous cell cancer with a median survival of 6.7 months. Defined by NUTM1 fusions, NC enhances oncogene transcription, including MYC. We investigated the ability of standard next-generation sequencing (NGS) to identify NUTM1 fusions and describe additional molecular features of NC. EXPERIMENTAL DESIGN: This study included 116 patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasm Proteins

Share to Nuclear Proteins

Share to Oncogene Proteins

Share to Oncogene Proteins, Fusion

Share to Registries

Source

Open in PubMed Open full text

Identifiers

PMID: 40704901
DOI: 10.1158/1078-0432.CCR-25-1071
PMCID: PMC12373430

Genes

NUTM1
ATM
BRCA1
BRD4
FAT1
FGFR3
KMT2D
LRP1B
MYC
PIK3CA
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry.PMID 40704901Read ↗

NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatmentSemantic proximity Read ↗

Immune biomarker landscape and fusion partner-phenotype associations in thoracic and head-and-neck NUT carcinoma.Semantic proximity Read ↗

Unveiling the Enigmatic Primary Pulmonary NUT Carcinoma with WHSC1L1::NUTM1-Rearrangement : A Case-Based Insight and Contemporary Literature ReviewSemantic proximity Read ↗

NUT Carcinoma—An Underdiagnosed MalignancySemantic proximity Read ↗

Primary Nuclear Protein in Testis (NUT) Carcinoma of the Lung: Clinical, Genetic, and Pathological CharacterizationSemantic proximity Read ↗

Primary renal NUT carcinoma identified by next-generation sequencing: A case report and literature reviewSemantic proximity Read ↗

Diagnosis of NUT Carcinoma Despite False-Negative Next-Generation Sequencing Results: A Case Report and Literature ReviewSemantic proximity Read ↗

Primary Thyroid NUT Carcinoma With High PD-L1 Expression and Novel Massive IGKV Gene Fusions: A Case Report With Treatment Implications and Literature ReviewSemantic proximity Read ↗

Primary Cutaneous NUT Carcinoma: Clinicopathologic and Genetic Study of 4 Cases.Semantic proximity Read ↗

Characterizing the molecular and clinical implications of NRG1 fusions in NSCLC through integrated RNA and DNA sequencing analysis.Semantic proximity Read ↗

NUTM1 Gene Fusions Characterize a Subset of Undifferentiated Soft Tissue and Visceral Tumors.Semantic proximity Read ↗

NUTM2A-AS1 as a potential key regulator in cancer: unraveling its ceRNA networks and impact on tumor biologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.