Article

Cell state-dependent chromatin targeting in NUT carcinoma

2023-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant transcriptional programming and chromatin dysregulation are common to most cancers. Whether by deranged cell signaling or environmental insult, the resulting oncogenic phenotype is typically manifested in transcriptional changes characteristic of undifferentiated cell growth. Here we analyze targeting of an oncogenic fusion protein, BRD4-NUT, composed of two normally independent chromat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59472cc3-8470-5b3a-bff1-adcc06a0409c
DOI: 10.1101/2023.04.18.537367

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell state-dependent chromatin targeting in NUT carcinomaDOI 10.1101/2023.04.18.537367Read

cMYC protein interactions and chromatin association in NUT carcinomaSemantic proximity Read

Mapping chromatin state and transcriptional response in CIC-DUX4 undifferentiated round cell sarcomaSemantic proximity Read

Chromatin Mechanisms Driving Cancer.Semantic proximity Read

“Z4” Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic MechanismSemantic proximity Read

<i>Brd4::Nutm1</i> fusion gene initiates NUT carcinoma <i>in vivo</i>Semantic proximity Read

<scp>BRD4</scp>and<scp>MYC</scp>: power couple in transcription and diseaseSemantic proximity Read

EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genesSemantic proximity Read

NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatmentSemantic proximity Read

Epigenomic profiling of neuroblastoma cell linesSemantic proximity Read

Epigenetic Regulation of Gene Expression in Cancer: Techniques, Resources, and AnalysisSemantic proximity Read

5-hydroxymethylcytosine profiling of cell-free DNA identifies bivalent genes that are prognostic of survival in high-risk neuroblastomaSemantic proximity Read

Chromatin Landscape of Cancer Cell Lines Identifies Enhancer SubtypesSemantic proximity Read