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Article

MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma

24 Apr 2025

Abstract excerpt

The oncoprotein MYCN drives malignancy in various cancer types, including neuroblastoma (NB). However, our understanding of the mechanisms underlying its transcriptional activity and oncogenic function, as well as effective strategies to target it, remains limited. We discovered that MYCN interacts with the transcriptional coactivator KAT2A, and this interaction significantly contributes to MYCN's activity in NB....

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PMID: 40274766
DOI: 10.1038/s41389-025-00557-2

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MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastomaPMID 40274766Read ↗

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