Article

MRGPRX4 is a novel bile acid receptor in cholestatic itch

2019-05-09

Abstract excerpt

Patients with liver diseases often suffer from chronic itch or pruritus, yet the itch-causing pruritogen(s) and their cognate receptor(s) remain largely elusive. Using transcriptomics and GPCR activation assays, we found that an orphan, primate specific MRGPRX4 is expressed in human dorsal root ganglia (hDRG) and selectively activated by bile acids. In situ hybridization and immunohistochemistry revealed that MRG...

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Literature Corpus work: 59d4b38e-ce97-58c0-ad0b-5730eeed2448
DOI: 10.1101/633446

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