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Article

ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates

28 Feb 2024

Abstract excerpt

ABSTRACT: Acute and chronic itch are prevalent and incapacitating, yet the neural mechanisms underlying both acute and chronic itch are just starting to be unraveled. Activated transcription factor 4 (ATF4) belongs to the ATF/CREB transcription factor family and primarily participates in the regulation of gene transcription. Our previous study has demonstrated that ATF4 is expressed in sensory neurons....

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PMID: 38422489
DOI: 10.1097/j.pain.0000000000003189

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