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Article

Defining the Contribution of Genetic Variants in MRGPRX4 With Pruritus in Paediatric Cholestasis: Evidence From Case-Control Study.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2026

Rodrigo Minna, Chien Daphne Chun-Che, Kawamoto Ryo, Limjunyawong Nathachit, Rajborirug Songyos, Dong Xinzhong, Karnsakul Wikrom

Abstract excerpt

BACKGROUND AND AIMS: Cholestatic pruritus is a debilitating symptom in paediatric liver disease with a complex and poorly understood pathogenesis. Recent evidence implicates the Mas-related G protein-coupled receptor X4 (MRGPRX4)-a bile acid receptor expressed in human dorsal root ganglia-as a potential mediator of itch signalling. Although MRGPRX4 harbours multiple single nucleotide variants (SNVs), their role...

Topics

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Alagille Syndrome
Bile Acids and Salts
Biliary Atresia
Cholangitis, Sclerosing
Cholestasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cholestasis, Intrahepatic

Receptors, Neuropeptide

Source

Identifiers

PMID: 41817014
DOI: 10.1111/liv.70587

Genes

MRGPRX4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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