Article

Catalytic region mimetics in Na+/H+ exchanger regulatory factor 4 suppress Guanylate Cyclase 2C activity to regulate enterotoxin triggered diarrhea

2024-12-13

Abstract excerpt

<title>Abstract</title> <p>Guanylate cyclase 2C (GCC), a receptor for bacterial heat-stable enterotoxin ST on the apical intestinal epithelium, generates cGMP and causes excessive intestinal secretion leading to diarrhea upon activation. This study reports that the C-terminal PSD95, Dlg1, ZO-1 (PDZ) domain interacting motif in GCC interacts with scaffolding proteins sodium-hydrogen exchanger regulatory factor (NH...

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Literature Corpus work: d70c09ce-3169-5e68-a22c-370c0ccc4ab3
DOI: 10.21203/rs.3.rs-5104524/v1

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