Article

Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation

2025-02-16

Abstract excerpt

Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin that drives contraction. Therapeutic intervention has until recently been limited to symptomatic relief or invasive procedures. However, small molecule modulators of cardiac myosin are promising therapeutic options t...

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Literature Corpus work: 59d31124-65e4-5615-b6aa-80cd7da44247
DOI: 10.1101/2025.02.12.637875

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