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Article

Systems biology approach to Wilson's disease.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Jun 2011

Burkhead Jason L, Gray Lawrence W, Lutsenko Svetlana

Abstract excerpt

Wilson's disease (WD) is a severe disorder of copper misbalance, which manifests with a wide spectrum of liver pathology and/or neurologic and psychiatric symptoms. WD is caused by mutations in a gene encoding a copper-transporting ATPase ATP7B and is accompanied by accumulation of copper in tissues, especially in the liver. Copper-chelation therapy is available for treatment of WD symptoms and is often...

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Identifiers

PMID: 21380607
DOI: 10.1007/s10534-011-9430-9
PMCID: PMC3106420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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