Article

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content

2020-05-23

Abstract excerpt

Rare genetic diseases preponderantly affect the nervous system with phenotypes spanning from neurodegeneration to neurodevelopmental disorders. This is the case for both Menkes and Wilson disease, arising from mutations in ATP7A and ATP7B, respectively. The ATP7A and ATP7B proteins localize to the Golgi and regulate copper homeostasis. We demonstrate conserved interactions between ATP7 paralogs with the COG comple...

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Literature Corpus work: 7d07f1a0-33ab-510f-aba9-0ba1cc2fbe86
DOI: 10.1101/2020.05.22.110627

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