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Article

Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.

Archives of biochemistry and biophysics - 15 Jul 2007

La Fontaine Sharon, Mercer Julian F B

Abstract excerpt

Copper is essential for human health and copper imbalance is a key factor in the aetiology and pathology of several neurodegenerative diseases. The copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of mammalian copper homeostasis. Their absence or malfunction leads to the genetically inherited disorders, Menkes and Wilson diseases, respectively....

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Identifiers

PMID: 17531189
DOI: 10.1016/j.abb.2007.04.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.PMID 17531189Read ↗

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Polarized trafficking and copper transport activity of ATP7B: A mutational approach to establish genotype-phenotype correlation in Wilson disease.Semantic proximity Read ↗

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