New Epitopes and Comparative Analysis of Children and Murine Immune Responses to Pertussis Toxin Subunits (S1–S5) Induced by Whole-Cell Pertussis Vaccination

Abstract excerpt

Pertussis toxin (Ptx) is a key virulence factor and protective antigen of Bordetella pertussis. Understanding its antigenic landscape is critical for improving vaccine formulations. This study compared the antigenic mapping of continuous epitopes recognized by children and murine antibodies against Ptx subunits S1–S5. Two libraries of nine overlapping 14-mer peptides, each encompassing the full-length Ptx sequence...

Topics

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• Bacterial Infections and Vaccines
• Bordetella pertussis
• Infective Endocarditis Diagnosis and Management
• Influenza Virus Research Studies
• Pertussis Vaccine
• Pneumonia and Respiratory Infections
• vaccines and immunoinformatics approaches
• Whooping Cough

Identifiers and source

Literature Corpus work

0fd07c04-9411-5996-a487-aebbba847f91

DOI

10.20944/preprints202602.1259.v1