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Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms

18 Mar 2024

Abstract excerpt

Type IV pili (T4P) are prevalent, polymeric surface structures in pathogenic bacteria, making them ideal targets for effective vaccines. However, bacteria have evolved efficient strategies to evade type IV pili-directed antibody responses. Neisseria meningitidis are prototypical type IV pili-expressing Gram-negative bacteria responsible for life threatening sepsis and meningitis. This species has evolved several...

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PMID: 38499587
DOI: 10.1038/s41467-024-46677-y

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