Article

Hypofucosylation promotes pertussis toxin binding to cell surface glycococonjugates and pertussis toxin-induced intracellular ERK signaling

2025-12-04

Abstract excerpt

<h4>ABSTRACT</h4> Pertussis (whooping cough) is caused by the bacterium Bordetella pertussis . Among the virulence factors produced by B. pertussis, pertussis toxin (PT) is responsible for key disease symptoms, including impacts on the immune system. PT is an AB 5 toxin, consisting of a single catalytic A subunit and five B subunits. The B pentamer recognizes cell surface glycans and facilitates intracellular...

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Literature Corpus work: f3fd4868-2477-5179-987b-77126ddeb11b
DOI: 10.64898/2025.12.03.692184

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