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Article

A Three-Dimensional Human Tissue-Engineered Lung Model to Study Influenza A Infection.

Tissue engineering. Part A - 1 Oct 2018

Bhowmick Rudra, Derakhshan Tahereh, Liang Yurong, Ritchey Jerry, Liu Lin, Gappa-Fahlenkamp Heather

Abstract excerpt

Influenza A virus (IAV) claims ∼250,000-500,000 lives annually worldwide. Currently, there are a few in vitro models available to study IAV immunopathology. Monolayer cultures of cell lines and primary lung cells (two-dimensional [2D] cell culture) is the most commonly used tool, however, this system does not have the in vivo-like structure of the lung and immune responses to IAV as it lacks the three-dimensional...

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Identifiers

PMID: 29732955
DOI: 10.1089/ten.TEA.2017.0449
PMCID: PMC6198767

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