Article

MAVS is Important for Antiviral Defense Against Influenza A Virus in a Human Respiratory Epithelium Model

2025-12-11

Abstract excerpt

The respiratory epithelium is an important immunological barrier and the first line of defense against influenza A virus. In mice and in various cellular systems, induction of type I interferons (IFNα/β) during IAV infections is known to depend on cytosolic RNA sensors RIG-I and MDA5 and on the adaptor molecule MAVS. Until now, it has not been possible to directly test the importance of MAVS for induction of IFNs...

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Literature Corpus work: 4d5eff78-dc2a-5975-8337-32c8b3757714
DOI: 10.64898/2025.12.09.693221

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