Article

Discovery of influenza drug resistance mutations and host therapeutic targets using a human airway chip

2019-06-27

Abstract excerpt

Here we demonstrate that influenza virus replication, host responses to infection, evolution through mutation or gene reassortment, and clinical efficacy of antiviral drugs can be reconstituted in a human Airway Chip microfluidic culture device. Modeling human-to-human transmission of infection in the continued presence of antiviral drugs on chips led to the emergence of clinically prevalent mutations responsible...

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Identifiers and source

Literature Corpus work: 76c97187-8be6-51d8-8f70-57b80bb98632
DOI: 10.1101/685552

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