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Adeno-Associated Virus (AAV) Vectors in the CNS

1 Jun 2005

Abstract excerpt

Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this vector system an excellent choice for both CNS gene therapy and basic neurobiological investigations. In vivo, the preponderance of AAV vector transduction occurs in neurons where it is possible to obtain long-term, stable gene expression with very little accompanying toxicity. Promoter selection, however, significantly...

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PMID: 15975010
DOI: 10.2174/1566523054064995

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