Article
Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants.
Nature communications - 26 Jul 2023
de Melo Guilherme Dias, Perraud Victoire, Alvarez Flavio, Vieites-Prado Alba, Kim Seonhee, Kergoat Lauriane, Coleon Anthony, Trüeb Bettina Salome, Tichit Magali, Piazza Aurèle, Thierry Agnès, Hardy David, Wolff Nicolas, Munier Sandie, Koszul Romain, Simon-Lorière Etienne, Thiel Volker, Lecuit Marc, Lledo Pierre-Marie, Renier Nicolas, Larrous Florence, Bourhy Hervé
Abstract excerpt
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has changed, with anosmia being less frequent. Here, we assessed the clinical, olfactory and neuroinflammatory conditions of golden hamsters infected with the original Wuhan SARS-CoV-2 strain, its isogenic ORF7-deletion mutant and three...
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