Article

The IKC-leptin axis functions as a molecular bridge between neurodevelopment and endocrine signaling

2026-01-05

Abstract excerpt

Kcnb1, a voltage-gated K⁺ channel widely expressed in brain, assembles with integrins to form integrin-K⁺ channel complexes (IKCs) in cortex and hypothalamus. Pathogenic KCNB1 variants cause Developmental and Epileptic Encephalopathy (DEE), and Kcnb1-null (Null) mice reproduce core neurodevelopmental defects alongside chronic hypoleptinemia, suggesting a leptin-IKC signaling axis. We find that Kcnb1, integrins, a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59961177-b582-5548-a4fa-ed3feb21f430
DOI: 10.64898/2026.01.05.697408

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The IKC-leptin axis functions as a molecular bridge between neurodevelopment and endocrine signalingDOI 10.64898/2026.01.05.697408Read

Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy.Semantic proximity Read

KCNQ1 regulates human neuronal development through mitochondrial and insulin signalling pathwaysSemantic proximity Read

Heterozygous Lepr Mutation Accelerates Alzheimer-like Neurodegeneration in db/+ Mice via CDK5 HyperactivationSemantic proximity Read

Differential Neuronal Targeting of a New and Two Known Calcium Channel β<sub>4</sub>Subunit Splice Variants Correlates with Their Regulation of Gene ExpressionSemantic proximity Read

LRRC37B is a species-specific regulator of voltage-gated channels and excitability in human cortical neuronsSemantic proximity Read

Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling.Semantic proximity Read

Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.Semantic proximity Read

Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.Semantic proximity Read

Disruption of the Homer1 coiled-coiled domain by a novel de novo human <i>HOMER1</i> variant impairs protein scaffolding, calcium signalling, and synaptogenesisSemantic proximity Read

Oligodendroglial deletion of the microcephaly gene Cit-k disrupts cortical connectivity and cognitive functionSemantic proximity Read

Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes.Semantic proximity Read

Milk Exosomes Cross the Blood-Brain Barrier in Murine Cerebral Cortex Endothelial Cells and Promote Dendritic Complexity in the Hippocampus and Brain Function in C57BL/6J MiceSemantic proximity Read