Article

LRRC37B is a species-specific regulator of voltage-gated channels and excitability in human cortical neurons

2022-12-21

Abstract excerpt

The enhanced cognitive abilities characterizing the human species result from specialized features of neurons and circuits, but the underlying molecular mechanisms remain largely unknown. Here we report that the hominid-specific gene LRRC37B encodes a novel receptor expressed in a subset of human cortical pyramidal neurons (CPNs). LRRC37B protein localizes at the axon initial segment (AIS), the specialized domain...

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Literature Corpus work: 7c5a501f-ef04-5b8c-94cc-137774ab8071
DOI: 10.1101/2022.12.21.521423

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