Article

KCNQ1 regulates human neuronal development through mitochondrial and insulin signalling pathways

2025-12-05

Abstract excerpt

KCNQ1 encodes a voltage-gated potassium channel implicated in various peripheral and neurological disorders, yet its role during human neuronal development remains unclear. To investigate this, we generated KCNQ1 knockouts (KO) in human induced pluripotent stem cell lines and differentiated them into neural stem cells (NSCs) and cortical neurons. KCNQ1 -deficient NSCs showed impaired neurite outgrowth, linked to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f1ba3f9-281a-563c-a5ed-18787c897201
DOI: 10.64898/2025.12.04.692265

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KCNQ1 regulates human neuronal development through mitochondrial and insulin signalling pathwaysDOI 10.64898/2025.12.04.692265Read

Neuronal KCNQ potassium channels: physiology and role in disease.Semantic proximity Read

Human iPSC-derived glutamatergic neurons with pathogenic KCNQ2 variants display hyperactive bursting phenotypes.Semantic proximity Read

Assessing the impact of mono- and bi-allelic deletions in <i>NRXN1</i> on synaptic functionSemantic proximity Read

KCNQ2 Loss-of-Function variants disrupt neuronal maturation via early hyperexcitability followed by maladaptive network remodelingSemantic proximity Read

Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic developmentSemantic proximity Read

A missense <i>KCNQ1</i> Mutation Impairs Insulin Secretion in Neonatal DiabetesSemantic proximity Read

Altered NRG1/ErbB4 signaling and cholesterol metabolism dysregulation are key pathomechanisms in VRK1-related motor neuropathies and motor neuron diseasesSemantic proximity Read

Chchd10 or Chchd2 are not Required for Human Motor Neuron Differentiation <i>In Vitro</i> but Modify Synaptic TranscriptomesSemantic proximity Read

Loss of Neurodevelopmental Gene <i>CASK</i> Disrupts Neural Connectivity in Human Cortical Excitatory NeuronsSemantic proximity Read

Characterization of Electrophysiological and Transcriptomic Alterations in Patient-Derived Neurons from CHAMP1 SyndromeSemantic proximity Read

Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome.Semantic proximity Read

Integrative transcriptomics and electrophysiological profiling of hiPSC-derived neurons identifies novel druggable pathways in Koolen-de Vries SyndromeSemantic proximity Read