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Article

Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy.

Cell death and differentiation - 1 Mar 2023

Bortolami Alessandro, Yu Wei, Forzisi Elena, Ercan Koray, Kadakia Ritik, Murugan Madhuvika, Fedele Denise, Estevez Irving, Boison Detlev, Rasin Mladen-Roko, Sesti Federico

Abstract excerpt

Potassium (K+) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K+ channel KCNB1 (Kv2.1) in neocortical development. Neuronal migration of glutamatergic neurons was impaired in the neocortices of KCNB1 null mice. Migratory defects persisted into the adult...

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Identifiers

PMID: 36207442
DOI: 10.1038/s41418-022-01072-2
PMCID: PMC9984485

Genes

KCNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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