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Differential Neuronal Targeting of a New and Two Known Calcium Channel β<sub>4</sub>Subunit Splice Variants Correlates with Their Regulation of Gene Expression

22 Jan 2014

Abstract excerpt

The β subunits of voltage-gated calcium channels regulate surface expression and gating of CaV1 and CaV2 α1 subunits and thus contribute to neuronal excitability, neurotransmitter release, and calcium-induced gene regulation. In addition, certain β subunits are targeted into the nucleus, where they interact directly with the epigenetic machinery. Whereas their involvement in this multitude of functions is...

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PMID: 24453333
DOI: 10.1523/jneurosci.3935-13.2014

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