Article
Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Oct 2018
Shin Bo-Chul, Cepeda Carlos, Estrada-Sánchez Ana María, Levine Michael S, Hodaei Laya, Dai Yun, Jung Jai, Ganguly Amit, Clark Peter, Devaskar Sherin U
Abstract excerpt
We created a neural-specific conditional murine glut3 (Slc2A3) deletion (glut3flox/flox/nestin-Cre+) to examine the effect of a lack of Glut3 on neurodevelopment. Compared with age-matched glut3flox/flox = WT and heterozygotes (glut3flox/+/nestin-Cre+), we found that a >90% reduction in male and female brain Glut3 occurred by postnatal day 15 (PN15) in glut3flox/flox/nestin-Cre+ This genetic manipulation caused a...
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