Article

Oligodendroglial deletion of the microcephaly gene Cit-k disrupts cortical connectivity and cognitive function

2026-08-08

Abstract excerpt

Neurodevelopmental disorders (NDDs) are increasingly recognized as disorders of brain connectivity and circuit dysfunction. Growing evidence suggests that glial cell and myelin abnormalities may actively contribute to these alterations. Yet, they have been often considered secondary consequences of impaired neuronal development rather than primary drivers of circuit dysfunction. Primary autosomal recessive microce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e86e536e-991a-5e25-b460-0dbceb77045e
DOI: 10.64898/2026.08.07.743469

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oligodendroglial deletion of the microcephaly gene Cit-k disrupts cortical connectivity and cognitive functionDOI 10.64898/2026.08.07.743469Read

Modeling primary microcephaly with human brain organoids reveals fundamental roles of CIT kinase activity.Semantic proximity Read

DYRK1A haploinsufficiency affects the development of astroglia and oligodendroglia, and axonal conductivity in the brainSemantic proximity Read

Oligodendrocyte-encoded Kir4.1 function is required for axonal integritySemantic proximity Read

Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndromeSemantic proximity Read

CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly.Semantic proximity Read

Mutations in CIT, encoding citron rho-interacting serine/threonine kinase, cause severe primary microcephaly in humans.Semantic proximity Read

Pathogenic KIF5C mutation disrupts dendritic spine maturation and mitochondrial trafficking in neurodevelopmental disorders.Semantic proximity Read

Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamicsSemantic proximity Read

Monoallelic<i>de novo</i>variants in<i>DDX17</i>cause a novel neurodevelopmental disorderSemantic proximity Read

De novo variants in MPP5 cause global developmental delay and behavioral changes.Semantic proximity Read

Ulk4 deficiency leads to hypomyelination in mice.Semantic proximity Read

Missense mutation in the activation segment of the kinase CK2 models Okur Chung neurodevelopmental disorder and alters the hippocampal glutamatergic synapseSemantic proximity Read