Article

Senescence targeting re-enables injury-responsive repair in a human RPE aging model

2026-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Aging is associated with progressive tissue dysfunction and impaired repair after injury. In the retinal pigment epithelium (RPE), these changes contribute to age-related macular degeneration (AMD), yet the mechanisms limiting repair remain incompletely understood. Here, we establish a longitudinal human embryonic stem cell (hESC)-derived RPE aging model that recapitulates key features of aged h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f7ec8f3-6cd2-5b4f-9d7f-33ac90be6db1
DOI: 10.64898/2026.06.26.722664

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Senescence targeting re-enables injury-responsive repair in a human RPE aging modelDOI 10.64898/2026.06.26.722664Read

New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular DiseasesSemantic proximity Read

Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degenerationSemantic proximity Read

Cellular Senescence Exacerbates Features of Aging in the EyesSemantic proximity Read

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degenerationSemantic proximity Read

Cellular Senescence in Health, Disease, and Lens AgingSemantic proximity Read

Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal agingSemantic proximity Read

Identifying Biomarkers of Retinal Pigment Epithelial Cell Stem Cell-derived RPE Cell Heterogeneity and Transplantation EfficacySemantic proximity Read

Single-cell transcriptomics reveals maturation of transplanted stem cell–derived retinal pigment epithelial cells toward native stateSemantic proximity Read

Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)Semantic proximity Read

Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–ChoroidSemantic proximity Read

Inducing Human Retinal Pigment Epithelium-like Cells from Somatic TissueSemantic proximity Read

Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic useSemantic proximity Read