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Article

Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma

1 Dec 2023

Abstract excerpt

Glaucoma, a chronic neurodegenerative disease, is a leading cause of age-related blindness worldwide and characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons. Previously, we developed a novel epigenetic rejuvenation therapy, based on the expression of the three transcription factors Oct4, Sox2, and Klf4 (OSK), which safely rejuvenates RGCs without altering cell identity in...

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PMID: 38060815
DOI: 10.1089/cell.2023.0074

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