Article

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

2025-08-05

Abstract excerpt

<title>Abstract</title> <p>SHP2 is a phosphatase and a critical mediator of receptor tyrosine kinase (RTK)-driven RAS/mitogen-activated protein kinase (MAPK) signaling. Despite promising preclinical data, SHP2 inhibitors have shown minimal clinical efficacy, with no defined clinical mechanisms of primary resistance. Here, we elucidate phosphorylation of SHP2 at tyrosine 62 (pY62) as a hotspot phosphorylation site...

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Literature Corpus work: e9f17344-844c-5ca3-af9d-77f3c73e77c9
DOI: 10.21203/rs.3.rs-7032881/v1

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