Article
Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer.
Cancer research - 1 Aug 2021
Osmulski Pawel A, Cunsolo Alessandra, Chen Meizhen, Qian Yusheng, Lin Chun-Lin, Hung Chia-Nung, Mahalingam Devalingam, Kirma Nameer B, Chen Chun-Liang, Taverna Josephine A, Liss Michael A, Thompson Ian M, Huang Tim H-M, Gaczynska Maria E
Abstract excerpt
Aggressive tumors of epithelial origin shed cells that intravasate and become circulating tumor cells (CTC). The CTCs that are able to survive the stresses encountered in the bloodstream can then seed metastases. We demonstrated previously that CTCs isolated from the blood of prostate cancer patients display specific nanomechanical phenotypes characteristic of cell endurance and invasiveness and patient...
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