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Poly‐aneuploid cancer cells promote evolvability, generating lethal cancer

6 Feb 2020

Abstract excerpt

Cancer cells utilize the forces of natural selection to evolve evolvability allowing a constant supply of heritable variation that permits a cancer species to evolutionary track changing hazards and opportunities. Over time, the dynamic tumor ecosystem is exposed to extreme, catastrophic changes in the conditions of the tumor-natural (e.g., loss of blood supply) or imposed (therapeutic). While the nature of these...

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PMID: 32952609
DOI: 10.1111/eva.12929

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