Article

IL-34 deficiency impairs FOXP3 <sup>+</sup> Treg function and increases susceptibility to autoimmunity

2022-02-06

Abstract excerpt

Immune homeostasis requires fully functional Tregs with a stable phenotype to control autoimmunity. Although IL-34 is a cytokine first described as mainly involved in monocyte cell survival and differentiation, we recently described its expression by CD8+ Tregs in a rat model of transplantation tolerance and by activated FOXP3+ CD4+ and CD8+ Tregs in human healthy individuals. However, its role in autoimmunity and...

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Literature Corpus work: 596fc5c6-7f2d-5f61-818b-2a825a1d14f2
DOI: 10.1101/2022.02.04.479184

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