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Article

TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2013

Chen Xin, Wu Xueqiang, Zhou Qiong, Howard O M Zack, Netea Mihai G, Oppenheim Joost J

Abstract excerpt

Several lines of evidence indicate the instability of CD4(+)Foxp3(+) regulatory T cells (Tregs). We have therefore investigated means of promoting the stability of Tregs. In this study, we found that the proportion of Tregs in mouse strains deficient in TNFR2 or its ligands was reduced in the thy...

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Source

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Identifiers

PMID: 23277487
DOI: 10.4049/jimmunol.1202659
PMCID: PMC3552130

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23277487-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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